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In tobamovirus Rep protein, the consensus sequences (GXXXXGKT and DEAD box in the helicase domain, and GDD and SGXXXTXXXNT in polymerase domain) were also conserved, except the last amino acid Thr in GXXXXGKT has been substituted by Ser in both the viruses (Figure 4)

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There remains considerable uncertainty about both the identity of these toxicants and the extent of smoke toxicant reductions needed to decrease individual smokers relative risks of smoking-related diseases

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